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As follow-up of Song`s experiments reported previously, this study was undertaken to observe pathologic changes in Imuran-treated renal homografts in dogs. Mongrel dogs weighing 15 to 20 kilograms were used in all experiments. Renal transplants were exchanged between animals. Imuran was administered twice a day per oral with daily doses of 3mg. per kilogram of body weight, and the first dose was given 24 hours before renal transplantation. Transplanted kidney were removed on the postoperative 1st, 3rd, 7th, 14th. 20th, and 30th day, and the were examined microscopically with Hematoxylin-Eosin staining. As comparing with the results of Song`s experiments which were untreated homotransplants, the appearance of characteristic microscopic changes of rejection (progressive destructive changes of vessels with infiltration of lymphocytes, polymorphonuclear leukocytes and plasma cell) was temporarily delayed and modified by Imuran administration, but ischemic changes developed imminently in later days.
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